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	viral hepatitis

Disease ID	1500
Disease	viral hepatitis
Definition	Inflammation of the liver due to infection with a virus. [HPO:probinson]
Synonym	infectious hepatitis (viral hepatitis) unspecified viral hepatitis unspecified viral hepatitis (disorder) vh - viral hepatitis viral hepatitis (disorder) viral hepatitis nos viral hepatitis, nos
DOID	DOID:1884
UMLS	C0042721
SNOMED-CT	SNOMEDCT_US_2016_09_01:3738000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:85) C0023890 \| cirrhosis \| 20 C0023895 \| liver disease \| 20 C0019204 \| hepatocellular carcinoma \| 7 C0019196 \| hepatitis c \| 5 C0001339 \| acute pancreatitis \| 4 C0023890 \| liver cirrhosis \| 4 C0002871 \| anemia \| 3 C0023903 \| liver cancer \| 3 C0019163 \| hepatitis b \| 3 C0008370 \| cholestasis \| 3 C0345905 \| intrahepatic cholangiocarcinoma \| 3 C0085293 \| hepatitis e \| 3 C0008325 \| cholecystitis \| 3 C0206698 \| cholangiocarcinoma \| 3 C0030305 \| pancreatitis \| 3 C0019158 \| hepatitis \| 2 C0002874 \| aplastic anemia \| 2 C0023895 \| liver diseases \| 2 C0267841 \| acalculous cholecystitis \| 2 C0036202 \| sarcoidosis \| 2 C0242350 \| erectile dysfunction \| 2 C0002892 \| pernicious anemia \| 1 C0024291 \| hemophagocytic syndrome \| 1 C0024314 \| lymphoproliferative disorder \| 1 C0041296 \| tuberculosis \| 1 C0023903 \| liver tumor \| 1 C0026975 \| myelitis \| 1 C0235974 \| pancreatic cancer \| 1 C0011991 \| diarrhoea \| 1 C0022661 \| end-stage renal disease \| 1 C0017658 \| glomerulonephritis \| 1 C0042769 \| virus infection \| 1 C0042769 \| viral disease \| 1 C0006142 \| breast cancer \| 1 C0011570 \| depression \| 1 C0026848 \| myopathies \| 1 C0011847 \| diabetes \| 1 C0002878 \| haemolytic anaemia \| 1 C0020532 \| hypersplenism \| 1 C0033860 \| psoriasis \| 1 C0030807 \| pemphigus \| 1 C0022658 \| renal disease \| 1 C0032285 \| pneumonia \| 1 C0024314 \| lymphoproliferative disorders \| 1 C0026764 \| myeloma \| 1 C0042870 \| vitamin d deficiency \| 1 C0021359 \| infertile \| 1 C0029106 \| opisthorchiasis \| 1 C0024299 \| lymphoma \| 1 C0010403 \| cryoglobulinemia \| 1 C0026764 \| multiple myeloma \| 1 C0034902 \| pure red cell aplasia \| 1 C0027813 \| neuritis \| 1 C0004626 \| bacterial pneumonia \| 1 C0010068 \| coronary artery disease \| 1 C0023418 \| leukemia \| 1 C0029134 \| optic neuritis \| 1 C0017920 \| glucose-6-phosphate dehydrogenase deficiency \| 1 C0281963 \| red cell aplasia \| 1 C0023434 \| chronic lymphocytic leukemia \| 1 C0020550 \| hyperthyroidism \| 1 C0178238 \| intestinal infection \| 1 C0032305 \| pneumocystis \| 1 C0042870 \| vitamin d defic \| 1 C0022658 \| kidney disease \| 1 C0152445 \| gallbladder hydrops \| 1 C0014868 \| esophagitis \| 1 C0011226 \| hepatitis d \| 1 C0032827 \| k deficiency \| 1 C0002871 \| anaemia \| 1 C1510472 \| drug addiction \| 1 C0023448 \| lymphocytic leukemia \| 1 C0011860 \| type 2 diabetes mellitus \| 1 C0018799 \| heart disease \| 1 C0018991 \| hemiplegia \| 1 C0003873 \| rheumatoid disease \| 1 C0036323 \| schistosomiasis \| 1 C0024301 \| follicular lymphoma \| 1 C0011860 \| type 2 diabetes \| 1 C0011849 \| diabetes mellitus \| 1 C0042769 \| viral infection \| 1 C0029456 \| osteoporosis \| 1 C0022350 \| dubin-johnson syndrome \| 1 C0442874 \| neuropathy \| 1 C0027121 \| inflammatory myopathies \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	(Waiting for update.)
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:135) 2 \| A2M \| 2.129 \| DISEASES 58 \| ACTA1 \| 1.654 \| DISEASES 203102 \| ADAM32 \| 2.948 \| DISEASES 101 \| ADAM8 \| 2.765 \| DISEASES 130 \| ADH6 \| 1.173 \| DISEASES 9370 \| ADIPOQ \| 1.503 \| DISEASES 174 \| AFP \| 5.054 \| DISEASES 197 \| AHSG \| 1.115 \| DISEASES 1645 \| AKR1C1 \| 2.244 \| DISEASES 1646 \| AKR1C2 \| 2.256 \| DISEASES 229 \| ALDOB \| 1.884 \| DISEASES 567 \| B2M \| 2.211 \| DISEASES 29994 \| BAZ2B \| 2.143 \| DISEASES 632 \| BGLAP \| 1.004 \| DISEASES 9254 \| CACNA2D2 \| 1.115 \| DISEASES 846 \| CASR \| 1.232 \| DISEASES 414062 \| CCL3L3 \| 1.22 \| DISEASES 912 \| CD1D \| 1.318 \| DISEASES 958 \| CD40 \| 1.258 \| DISEASES 959 \| CD40LG \| 5.787 \| DISEASES 9308 \| CD83 \| 1.524 \| DISEASES 942 \| CD86 \| 1.616 \| DISEASES 79094 \| CHAC1 \| 1.663 \| DISEASES 339390 \| CLEC4G \| 1.968 \| DISEASES 283420 \| CLEC9A \| 1.503 \| DISEASES 493753 \| COA5 \| 2.783 \| DISEASES 1363 \| CPE \| 3.498 \| DISEASES 1378 \| CR1 \| 1.146 \| DISEASES 1490 \| CTGF \| 1.306 \| DISEASES 4283 \| CXCL9 \| 1.549 \| DISEASES 2833 \| CXCR3 \| 1.756 \| DISEASES 1544 \| CYP1A2 \| 1.895 \| DISEASES 1565 \| CYP2D6 \| 2.052 \| DISEASES 1576 \| CYP3A4 \| 1.094 \| DISEASES 51428 \| DDX41 \| 1.228 \| DISEASES 23586 \| DDX58 \| 1.706 \| DISEASES 160851 \| DGKH \| 2.277 \| DISEASES 285193 \| DUSP28 \| 2.867 \| DISEASES 1847 \| DUSP5 \| 1.853 \| DISEASES 10209 \| EIF1 \| 1.391 \| DISEASES 3692 \| EIF6 \| 1.189 \| DISEASES 132884 \| EVC2 \| 1.365 \| DISEASES 2152 \| F3 \| 1.904 \| DISEASES 2155 \| F7 \| 1.296 \| DISEASES 2157 \| F8 \| 1.612 \| DISEASES 355 \| FAS \| 3.152 \| DISEASES 356 \| FASLG \| 3.106 \| DISEASES 2214 \| FCGR3A \| 1.151 \| DISEASES 23767 \| FLRT3 \| 1.576 \| DISEASES 50943 \| FOXP3 \| 1.778 \| DISEASES 2641 \| GCG \| 1.602 \| DISEASES 728441 \| GGT2 \| 3.979 \| DISEASES 27333 \| GOLIM4 \| 1.457 \| DISEASES 51280 \| GOLM1 \| 1.724 \| DISEASES 2719 \| GPC3 \| 1.525 \| DISEASES 2875 \| GPT \| 1.982 \| DISEASES 8971 \| H1FX \| 1.444 \| DISEASES 3030 \| HADHA \| 4.19 \| DISEASES 3043 \| HBB \| 1.575 \| DISEASES 3077 \| HFE \| 3.358 \| DISEASES 3009 \| HIST1H1B \| 1.015 \| DISEASES 3113 \| HLA-DPA1 \| 2.264 \| DISEASES 3117 \| HLA-DQA1 \| 1.613 \| DISEASES 3123 \| HLA-DRB1 \| 1.551 \| DISEASES 3188 \| HNRNPH2 \| 1.055 \| DISEASES 3240 \| HP \| 3.275 \| DISEASES 3339 \| HSPG2 \| 1.279 \| DISEASES 3451 \| IFNA17 \| 2.106 \| DISEASES 3440 \| IFNA2 \| 3.68 \| DISEASES 3456 \| IFNB1 \| 2.945 \| DISEASES 3586 \| IL10 \| 2.618 \| DISEASES 3605 \| IL17A \| 1.194 \| DISEASES 3665 \| IRF7 \| 1.412 \| DISEASES 10379 \| IRF9 \| 2.55 \| DISEASES 9636 \| ISG15 \| 1.07 \| DISEASES 3702 \| ITK \| 1.093 \| DISEASES 9622 \| KLK4 \| 2.3 \| DISEASES 3821 \| KLRC1 \| 1.019 \| DISEASES 3875 \| KRT18 \| 2.291 \| DISEASES 3880 \| KRT19 \| 2.027 \| DISEASES 3855 \| KRT7 \| 1.775 \| DISEASES 246269 \| LACE1 \| 1.356 \| DISEASES 3965 \| LGALS9 \| 1.704 \| DISEASES 4017 \| LOXL2 \| 1.134 \| DISEASES 116135 \| LRRC3B \| 1.365 \| DISEASES 57506 \| MAVS \| 1.061 \| DISEASES 259283 \| MDS2 \| 1.366 \| DISEASES 10724 \| MGEA5 \| 1.001 \| DISEASES 284424 \| MIR7-3HG \| 3.078 \| DISEASES 4312 \| MMP1 \| 1.316 \| DISEASES 4599 \| MX1 \| 2.319 \| DISEASES 4615 \| MYD88 \| 1.374 \| DISEASES 259197 \| NCR3 \| 1.047 \| DISEASES 57446 \| NDRG3 \| 1.509 \| DISEASES 4739 \| NEDD9 \| 2.092 \| DISEASES 4814 \| NINJ1 \| 1.196 \| DISEASES 246734 \| NPCDR1 \| 2.192 \| DISEASES 8504 \| PEX3 \| 1.352 \| DISEASES 30814 \| PLA2G2E \| 1.978 \| DISEASES 5355 \| PLP2 \| 1.407 \| DISEASES 26064 \| RAI14 \| 1.648 \| DISEASES 6014 \| RIT2 \| 3.411 \| DISEASES 56254 \| RNF20 \| 1.25 \| DISEASES 51091 \| SEPSECS \| 2.735 \| DISEASES 5265 \| SERPINA1 \| 3.305 \| DISEASES 12 \| SERPINA3 \| 1.164 \| DISEASES 6906 \| SERPINA7 \| 1.015 \| DISEASES 6318 \| SERPINB4 \| 1.438 \| DISEASES 462 \| SERPINC1 \| 2.11 \| DISEASES 10864 \| SLC22A7 \| 1.648 \| DISEASES 94161 \| SNORD46 \| 1.076 \| DISEASES 26800 \| SNORD49A \| 2.401 \| DISEASES 8651 \| SOCS1 \| 1.468 \| DISEASES 9021 \| SOCS3 \| 1.077 \| DISEASES 6654 \| SOS1 \| 1.775 \| DISEASES 54558 \| SPATA6 \| 1.581 \| DISEASES 6736 \| SRY \| 1.215 \| DISEASES 6772 \| STAT1 \| 2.834 \| DISEASES 23336 \| SYNM \| 1.32 \| DISEASES 6938 \| TCF12 \| 1.578 \| DISEASES 26136 \| TES \| 1.001 \| DISEASES 7018 \| TF \| 3.393 \| DISEASES 7056 \| THBD \| 1.578 \| DISEASES 284486 \| THEM5 \| 1.601 \| DISEASES 7099 \| TLR4 \| 1.585 \| DISEASES 51284 \| TLR7 \| 2.107 \| DISEASES 54106 \| TLR9 \| 1.669 \| DISEASES 53345 \| TM6SF2 \| 1.947 \| DISEASES 7124 \| TNF \| 3.831 \| DISEASES 7133 \| TNFRSF1B \| 1.094 \| DISEASES 8718 \| TNFRSF25 \| 2.517 \| DISEASES 7318 \| UBA7 \| 1.004 \| DISEASES 7360 \| UGP2 \| 2.711 \| DISEASES 55665 \| URGCP \| 1.171 \| DISEASES 220001 \| VWCE \| 1.679 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1500
Disease	viral hepatitis
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:69) HP:0001394 \| Hepatic cirrhosis \| 24 HP:0001399 \| Liver failure \| 10 HP:0001402 \| Hepatocellular carcinoma \| 8 HP:0030731 \| Carcinoma \| 8 HP:0002896 \| Liver cancer \| 4 HP:0001903 \| Anemia \| 4 HP:0001733 \| Pancreatic inflammation \| 3 HP:0006554 \| Acute hepatic failure \| 3 HP:0001410 \| Decreased liver function \| 3 HP:0030153 \| Cholangiocarcinoma \| 3 HP:0001735 \| Acute pancreatitis \| 3 HP:0001082 \| Cholecystitis \| 3 HP:0004448 \| Fulminant hepatic failure \| 3 HP:0000802 \| Erectile dysfunction \| 2 HP:0001915 \| Aplastic anemia \| 2 HP:0100626 \| Chronic hepatic failure \| 2 HP:0001397 \| Hepatic steatosis \| 2 HP:0001395 \| Hepatic fibrosis \| 2 HP:0200123 \| Chronic liver inflammation \| 2 HP:0001396 \| Cholestasis \| 2 HP:0012115 \| Liver inflammation \| 2 HP:0000855 \| Insulin resistance \| 2 HP:0002960 \| Autoimmune condition \| 2 HP:0002716 \| Lymph node hyperplasia \| 1 HP:0002027 \| Abdominal pain \| 1 HP:0003613 \| Antiphospholipid antibodies \| 1 HP:0100653 \| Optic neuritis \| 1 HP:0002894 \| Neoplasia of the pancreas \| 1 HP:0002301 \| Hemiplegia \| 1 HP:0000716 \| Depression \| 1 HP:0000819 \| Diabetes mellitus \| 1 HP:0001878 \| Haemolytic anaemia \| 1 HP:0000969 \| Dropsy \| 1 HP:0100543 \| Cognitive deficits \| 1 HP:0000099 \| Glomerular nephritis \| 1 HP:0001677 \| Coronary artery disease \| 1 HP:0002664 \| Neoplasia \| 1 HP:0010702 \| Hypergammaglobulinaemia \| 1 HP:0000939 \| Osteoporosis \| 1 HP:0100512 \| Vitamin D deficiency \| 1 HP:0005550 \| Chronic lymphatic leukemia \| 1 HP:0001873 \| Low platelet count \| 1 HP:0003002 \| Breast carcinoma \| 1 HP:0001824 \| Weight loss \| 1 HP:0006824 \| Cranial nerve palsy \| 1 HP:0100778 \| Cryoglobulinemia \| 1 HP:0006775 \| Multiple myeloma \| 1 HP:0002090 \| Pneumonia \| 1 HP:0002721 \| Immunodeficiency \| 1 HP:0005523 \| Lymphoproliferative disorder \| 1 HP:0100633 \| Inflammation of the esophagus \| 1 HP:0003765 \| Psoriasis \| 1 HP:0004395 \| Malnutrition \| 1 HP:0000836 \| Overactive thyroid \| 1 HP:0011892 \| Vitamin K deficiency \| 1 HP:0010310 \| Chylothorax \| 1 HP:0012410 \| Pure red cell aplasia \| 1 HP:0001971 \| Hypersplenism \| 1 HP:0001511 \| Prenatal onset growth retardation \| 1 HP:0001909 \| Leukemia \| 1 HP:0002665 \| Lymphoma \| 1 HP:0001945 \| Fever \| 1 HP:0001289 \| Confusion \| 1 HP:0012531 \| Pain \| 1 HP:0001919 \| Acute renal failure \| 1 HP:0003774 \| End-stage renal failure \| 1 HP:0012486 \| Inflammation of spinal cord \| 1 HP:0000952 \| Yellow skin \| 1 HP:0012215 \| Testicular microlithiasis \| 1

Disease ID	1500
Disease	viral hepatitis
Manually Symptom	UMLS \| Name(Total Manually Symptoms:94) C2711227 \| hepatic steatosis C2707258 \| infections C2700513 \| aplastic anemia C2364133 \| infection C2364074 \| drug abuse C2364072 \| depression C2363741 \| hiv-1 infection C2203646 \| jaundice C2186532 \| liver disease C2073625 \| pleural effusion C2004456 \| postnecrotic cirrhosis C1963165 \| malabsorption C1963154 \| renal failure C1963135 \| hepatic necrosis C1963083 \| cholecystitis C1962972 \| proteinuria C1883018 \| severe aplastic anemia C1623038 \| cirrhosis C1611280 \| allergy C1608426 \| compensated cirrhosis C1512411 \| hepatocellular carcinoma C1405749 \| hepatorenal syndrome C1393529 \| vascular complications C1387528 \| acute hemolytic anemia C1000483 \| anemia C0948906 \| bacterial allergy C0936254 \| polyradiculoneuritis C0919725 \| digital necrosis C0877561 \| cholecystocholangitis C0796095 \| c syndrome C0542241 \| toxemia C0442886 \| secondary infection C0400929 \| subacute hepatic failure C0259744 \| dysproteinemia C0240805 \| prodrome C0239946 \| liver fibrosis C0239946 \| hepatic fibrosis C0234935 \| acute urticaria C0162557 \| fulminant hepatic failure C0162557 \| acute liver failure C0162557 \| acute hepatic failure C0151798 \| liver necrosis C0149678 \| ebv infection C0085605 \| hepatic failure C0040188 \| tic disorders C0040149 \| subacute thyroiditis C0040127 \| thyroid crisis C0040034 \| thrombocytopenia C0038826 \| superinfection C0038395 \| streptococcal infection C0038353 \| gastric dilatation C0038160 \| staphylococcal infection C0037284 \| skin lesions C0037274 \| dermatologic disorders C0036323 \| schistosomiasis C0030326 \| panniculitis C0030312 \| pancytopenia C0027121 \| myositis C0025010 \| measles C0024537 \| tertian malaria C0024141 \| systemic lupus erythematosus C0023895 \| liver diseases C0023890 \| liver cirrhosis C0023890 \| hepatic cirrhosis C0022660 \| acute kidney failure C0022658 \| renal disease C0022408 \| arthropathy C0022408 \| arthropathies C0021832 \| intestinal parasites C0020437 \| hypercalcaemia C0020433 \| bilirubinemia C0019693 \| hiv infection C0019212 \| hepato-renal syndrome C0019151 \| hepatic encephalopathy C0019151 \| coma hepaticum C0019147 \| hepatic coma C0019087 \| hemorrhagic diathesis C0018799 \| heart disorders C0018784 \| sensorineural hearing loss C0015695 \| fatty liver C0015469 \| facial paralysis C0011860 \| diabetes C0011849 \| diabetes mellitus C0010403 \| cryoglobulinemia C0010356 \| cross infection C0008372 \| intrahepatic cholestasis C0008370 \| cholestasis C0006840 \| candidiasis C0006111 \| brain disorders C0005416 \| biliary dyskinesia C0003864 \| arthritis C0002881 \| congenital hemolytic anemia C0002879 \| acquired hemolytic anemia C0001339 \| acute pancreatitis
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:28) C0023890 \| cirrhosis \| 22 C0023895 \| liver disease \| 19 C0009450 \| infection \| 17 C0239946 \| liver fibrosis \| 16 C0019204 \| hepatocellular carcinoma \| 8 C0085605 \| hepatic failure \| 3 C0001339 \| acute pancreatitis \| 3 C0162557 \| acute liver failure \| 3 C0008325 \| cholecystitis \| 3 C0162557 \| fulminant hepatic failure \| 3 C0002871 \| anemia \| 3 C0021311 \| infections \| 2 C0002874 \| aplastic anemia \| 2 C0023890 \| liver cirrhosis \| 2 C0008370 \| cholestasis \| 2 C0796095 \| c syndrome \| 2 C0239946 \| hepatic fibrosis \| 2 C0023895 \| liver diseases \| 1 C0011849 \| diabetes mellitus \| 1 C0015695 \| fatty liver \| 1 C0022346 \| jaundice \| 1 C0010403 \| cryoglobulinemia \| 1 C0011847 \| diabetes \| 1 C0022658 \| renal disease \| 1 C0036323 \| schistosomiasis \| 1 C0040034 \| thrombocytopenia \| 1 C0038826 \| superinfection \| 1 C0011570 \| depression \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:1)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs25487	24018491	7515	XRCC1	umls:C0042721	BeFree	The XRCC1 rs25487 polymorphism may influence the development of cirrhosis in viral hepatitis patients, and additional investigation will be necessary.	0.000542884	2014	XRCC1	19	43551574	T	C

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1500
Disease	viral hepatitis
Case	(Waiting for update.)

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